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- Title
Onco-Hypertension: A Continuously Developing Field between Cancer and Hypertension.
- Authors
Totolici, Stefan; Vrabie, Ana-Maria; Badila, Elisabeta; Weiss, Emma
- Abstract
The prognosis of cancer patients has greatly improved in the last years, owing to the development of novel chemotherapeutic agents. However, this progress comes with an increasing occurrence of cardiovascular adverse reactions. A serious side effect is arterial hypertension (HT), which is the most frequent comorbidity encountered in cancer patients, influencing the outcomes in cancer survivors. Even though secondary HT related to specific chemotherapeutic agents, such as vascular endothelial growth factor inhibitors, is usually mild and reversible, in rare instances it can be severe, leading to discontinuation of chemotherapy. In addition, HT per se has been studied as a potential risk factor for cancer development. The relationship is even more complex than previously thought, as concerning evidence recently highlighted the potential oncogenic effects of antihypertensive drugs, particularly thiazide diuretics, which may increase the risk of skin cancer. As a result, in light of the similar risk factors and overlapping pathophysiological mechanisms between HT and cancer, a promising concept of onco-hypertension has emerged, aiming to improve the understanding of the complicated interplay between these two pathologies and maintain a balance between the efficacy and risks of both antihypertensive drugs and chemotherapy agents.
- Subjects
VASCULAR endothelial growth factor antagonists; ANTIHYPERTENSIVE agents; HYPERTENSION; DISEASE risk factors
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 6, p3442
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25063442