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- Title
Thrombin-activated platelets induce proliferation of human skin fibroblasts by stimulating autocrine production of insulin-like growth factor-1.
- Authors
Giacco, Ferdinando; Perruolo, Giuseppe; D'Agostino, Elio; Fratellanza, Giorgio; Perna, Enzo; Misso, Saverio; Saldalamacchia, Gennaro; Oriente, Francesco; Fiory, Francesca; Miele, Claudia; Formisano, Salvatore; Beguinot, Francesco; Formisano, Pietro
- Abstract
The article presents research which argued that thrombin-activated platelets induce proliferation of human skin fibroblasts. This study also investigated the molecular mechanisms by which the local application of activated platelets can promote growth effects in wound healing processes. Further elucidation of such mechanisms may determine novel and improved therapeutic strategies for the treatment of diabetic complications.
- Subjects
BLOOD platelets; THROMBIN; BLOOD coagulation factors; FIBROBLASTS; BIOCHEMISTRY
- Publication
FASEB Journal, 2006, Vol 20, Issue 13, p2402
- ISSN
0892-6638
- Publication type
Article
- DOI
10.1096/fj.06-6104fje