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- Title
Novel Hybrid Peptide Cecropin A (1-8)-LL37 (17-30) with Potential Antibacterial Activity.
- Authors
Xu-Biao Wei; Ru-Juan Wu; Da-Yong Si; Xiu-Dong Liao; Lu-Lu Zhang; Ri-Jun Zhang
- Abstract
Hybridizing different antimicrobial peptides (AMPs) is a particularly successful approach to obtain novel AMPs with increased antimicrobial activity but minimized cytotoxicity. The hybrid peptide cecropin A (1-8)-LL37 (17-30) (C-L) combining the hydrophobic N-terminal fragment of cecropin A (C) with the core antimicrobial fragment of LL37 (L) was designed and synthesized. C-L showed higher antibacterial activity against all indicator strains than C and L, and no hemolytic activity to sheep erythrocytes was observed. C-L kills bacterial cells and causes disruption of surface structure, as determined by scanning electron microscopy. Synergistic effects were observed in the combination of C-L with several antibiotics (chloramphenicol, thiamphenicol, or neomycin sulfate) against Escherichia coli and Staphylococcus aureus.
- Subjects
PEPTIDE antibiotics; ANTI-infective agents; ERYTHROCYTES; CELL-mediated cytotoxicity; BACTERIAL cells; CHLORAMPHENICOL; THIAMPHENICOL
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 7, p983
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17070983