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- Title
High Serum YKL-40 Level in Patients with COPD Is Related to Hypoxemia and Disease Severity.
- Authors
Gumus, Aziz; Kayhan, Servet; Cinarka, Halit; Kirbas, Aynur; Bulmus, Necati; Yavuz, Asiye; Sahin, Unal; Ozkaya, Sevket
- Abstract
Chronic obstructive pulmonary disease (COPD) is a major health problem with increasing morbidity and mortality throughout the world. YKL-40 is a chitin-binding glycoprotein consisting of 383 amino acids, with a molecular mass of 40 kDa, and its serum level is elevated in inflammatory diseases. YKL-40 is a newly recognized biomarker of inflammation and has not been thoroughly investigated in COPD. The aim of the study is to investigate the relationship between serum YKL-40 levels and severity of COPD. The study population consisted of 52 patients with COPD with the mean age of 60.2 ± 10.1 years. The serum YKL-40 level increased significantly with increasing age (p = 0.022, r = 0.346). In COPD patients, high serum YKL-40 level is correlated to low forced expiratory volume at 1 second (FEV1, percent of predicted) (r = −0.277, p = 0.047). Moreover, high serum YKL-40 level is correlated to low arterial oxygen pressure (PaO2, mmHg) (r = −0.387, p = 0.005). The mean serum YKL-40 level was found as 243.1 ± 129.2 ng/ml in COPD patients with desaturation during 6-minute walk test (6MWT) and this value was higher than the mean serum YKL-40 level (155.8 ± 59.1 ng/ml) of COPD patients without desaturation during 6MWT (p = 0.004). This study demonstrated that high serum YKL-40 levels were correlated to severity of COPD. We propose that circulating YKL-40 levels could be a biomarker for hypoxemia and decline in lung function.
- Subjects
OBSTRUCTIVE lung diseases patients; HYPOXEMIA; CHITIN; GLYCOPROTEINS; SERUM; BIOMARKERS; INFLAMMATION
- Publication
Tohoku Journal of Experimental Medicine, 2013, Vol 229, Issue 2, p163
- ISSN
0040-8727
- Publication type
Article
- DOI
10.1620/tjem.229.163