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- Title
Cancer as a metabolic disease.
- Authors
Seyfried, Thomas N.; Shelton, Laura M.
- Abstract
Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention.
- Subjects
ENERGY metabolism; BIOENERGETICS; PHOSPHORYLATION; CHEMICAL reactions; CANCER cells
- Publication
Nutrition & Metabolism, 2010, Vol 7, p7
- ISSN
1743-7075
- Publication type
Article
- DOI
10.1186/1743-7075-7-7