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- Title
Inhibition of Aortic Intimal Hyperplasia and Vascular Smooth Muscle Proliferation and Extracellular Matrix Protein Expressions by Astragalus–Angelica Combination.
- Authors
Yan, Huifang; Peng, Xiwei; Xu, Hao; Zhu, Jiahuan; Deng, Changqing
- Abstract
VSMC proliferation and ECM deposition always resulted in intimal hyperplasia. Astragalus–Angelica combination has a protective effect on the cardiovascular system. The inhibition effect of different Astragalus–Angelica combination on the hyperplastic intima after vascular balloon injury in rats was investigated in this study. Astragalus–Angelica combination can inhibit the intima hyperplasia after balloon injury, in which a 1:1 ratio shows excellent results. Astragalus–Angelica combination can enhance the expression of smooth muscle α-actin (SMа-actin) and inhibit the expression of proliferating cell nuclear antigen (PCNA), cyclin D1, cyclin E, collagen I (Col-I), fibronectin (FN), and matrix metallopeptidase-9 (MMP-9) in hyperplastic intima, suggesting that Astragalus–Angelica combination can inhibit the intimal hyperplasia of blood vessels in rats. The mechanism is related to the inhibition of PI3K/Akt signaling pathway activation and thereby inhibits the phenotypic transformation and cell proliferation of VSMCs and thus inhibits the extracellular matrix (ECM) deposition of vascular wall during intimal hyperplasia.
- Subjects
EXTRACELLULAR matrix proteins; COLLAGEN; FIBRONECTINS; COMBINATION drug therapy; MUSCLE proteins; ANIMAL experimentation; NUCLEAR proteins; HYPERPLASIA; CELL cycle proteins; ANGELICA (Plants); VASCULAR smooth muscle; GENE expression; RATS; MATRIX metalloproteinases; CELLULAR signal transduction; CELL proliferation; ASTRAGALUS (Plants); AORTA; CATHETERIZATION; PHENOTYPES
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2018, Vol 2018, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2018/1508637