We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Re-irradiation using proton beam therapy combined with weekly intra-arterial chemotherapy for recurrent oral cancer.
- Authors
Hayashi, Yuichiro; Nakamura, Tatsuya; Mitsudo, Kenji; Kimura, Kanako; Yamaguchi, Hisashi; Ono, Takashi; Azami, Yusuke; Takayama, Kanako; Hirose, Katsumi; Yabuuchi, Tomonori; Suzuki, Motohisa; Hatayama, Yoshiomi; Kikuchi, Yasuhiro; Wada, Hitoshi; Fuwa, Nobukazu; Hareyama, Masato; Tohnai, Iwai
- Abstract
Aim The purpose of this study was to clarify the efficacy and toxicities of re-irradiation using proton beam therapy combined with weekly intra-arterial chemotherapy for recurrent oral cancer. Methods Between October 2009 and July 2014, 34 patients who had recurrent oral cancer were treated by proton beam therapy combined with intra-arterial infusion chemotherapy at the Southern Tohoku Proton Therapy Center, Japan. Results For all patients, the median follow-up was 25 months (range, 3-77 months). After treatment, 22 patients (65%) achieved a complete response, and 12 patients (35%) achieved a partial response at the primary tumor site. One-year and 2-year overall survival (OS) rates were 62% and 42%, respectively. One-year and 2-year LC rates were 77% and 60%, respectively. No treatment-related deaths were observed during the treatment and follow-up periods. Conclusion Re-irradiation using proton beam therapy combined with weekly intra-arterial chemotherapy improved OS and local control rates compared with other treatment modalities and could become a new treatment modality for patients with recurrent oral cancer.
- Subjects
PROTON therapy -- Reporting; IRRADIATION; TREATMENT of oral cancer; CANCER chemotherapy; INTRA-arterial infusions; TREATMENT effectiveness; COMBINED modality therapy; CANCER relapse; CANCER treatment
- Publication
Asia Pacific Journal of Clinical Oncology, 2017, Vol 13, Issue 5, pe394
- ISSN
1743-7555
- Publication type
Article
- DOI
10.1111/ajco.12502