We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of vitamin B on murine embryonic dexamethasone-induced cleft palates using H-NMR-based metabonomic analysis.
- Authors
Xiaohua Wu; Jinglin Zhou; Jing Huang; Han Huang; Bin Xu; Xiaoyan Wang; Pengchi Deng; Wei Li; Xiangli Kong; Bing Shi
- Abstract
Metabonomics using proton nuclear magnetic resonance (H-NMR) spectroscopy and multivariate data analysis of blood plasma samples can be used to characterize metabolic differences between healthy and diseased organisms, which can reveal important information about the causes of the disease. Here we evaluated whether the H-NMR-based metabonomic method can detect differences in blood plasma between healthy pregnant mice (outbred C57BL/6J strain) and pregnant mice injected with dexamethasone (Dex) to induce cleft palate. Both groups were injected with vitamin B. We found some metabolic differences from the 'outliers' among the mice, indicating that vitamin B protected against Dex-induced Cleft lip with or without palate (CLP) formation.
- Subjects
VITAMIN B12; VITAMIN B12 in animal nutrition; MARMOSA; DEXAMETHASONE; CLEFT palate; PROTON magnetic resonance spectroscopy; MULTIVARIATE analysis; BLOOD plasma; LABORATORY mice
- Publication
Metabolomics, 2010, Vol 6, Issue 4, p467
- ISSN
1573-3882
- Publication type
Article
- DOI
10.1007/s11306-010-0214-y