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- Title
Genetic alterations in lymphoblastic leukaemia / lymphoma – a practical guide to WHO HAEM5.
- Authors
Steinemann 1, Doris; Dawidowska Ph.D, DSc 2, Małgorzata; Russell Ph.D 3, Lisa J; Harrison Ph.D 4, Christine J; Göhring 5, Gudrun
- Abstract
We present a practical guide for analyzing the genetic aspects of lymphoblastic leukaemia/lymphoma according to the 5th edition of the World Health Organization (WHO) classification of haematolymphoid neoplasms (WHO-HAEM5) issued in 2024. The WHO-HAEM5 acknowledges the increasing importance of genetics in the diagnosis of lymphoid neoplasia. Classification is based on the established genetic subtypes according to cell lineage, with precursor cell neoplasms followed by mature malignancies. This guide describes those genetic abnormalities in acute precursor B- and T-cell neoplasms required for risk stratification, and for treatment, providing diagnostic algorithms under the headings of 'essential' and 'desirable' diagnostic criteria.
- Subjects
LYMPHOBLASTIC leukemia; TUMOR classification; TUMOR diagnosis; TUMOR genetics; WORLD Health Organization
- Publication
Medizinische Genetik, 2024, Vol 36, Issue 1, p39
- ISSN
0936-5931
- Publication type
Article
- DOI
10.1515/medgen-2024-2007