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- Title
Tuberculosis incidence in a cohort of individuals infected with human T-lymphotropic virus type 1 (HTLV-1) in Salvador, Brazil.
- Authors
Rios Grassi, Maria Fernanda; dos Santos, Normeide Pedreira; Lírio, Monique; Kritski, Afrânio Lineu; Chagas Almeida, Maria da Conceição; Santana, Leonardo Pereira; Lázaro, Noilson; Dias, Juarez; Netto, Eduardo Martins; Galvão-Castro, Bernardo; Grassi, Maria Fernanda Rios
- Abstract
<bold>Background: </bold>Few reports have investigated the association between human T-lymphotropic virus type 1 (HTLV-1) and tuberculosis (TB) in countries where both infections are endemic. This study estimates the incidence of TB in a cohort infected with HTLV-1, compared with non-infected individuals, over a ten-year period.<bold>Methods: </bold>Retrospective cohort study involving the cross-matching of records of individuals for whom a HTLV serology was performed at a referral center for HTLV (CHTLV) with a database of TB cases from Sinan-the Information System on Diseases of Compulsory Declaration between 2002 and 2012.<bold>Results: </bold>From a cohort of 6,495 individuals, 1,711 were infected with HTLV-1. A total of 73 TB cases occurred during the study period: 33 HTLV-1-infected patients and 40 uninfected individuals. The incidence density for TB in the HTLV-1 infected group was 3.3 person-years per 1,000 individuals and 1.1 person-years per 1,000 individuals in the group HTLV-1 uninfected group. The relative risk of developing TB in the group of patients infected with HTLV-1 was 2.6 (CI 95 % 1.6-4.2) in comparison with HTLV-1 uninfected group. Compared to individuals with isolated TB, those in the HTLV-1 infected group who had TB were older (p = 0.005) and had lower education levels (p = 0.02). No differences were observed with respect to the clinical/radiological presentation, nor in the outcome of TB and prevalence of HIV infection, when comparing among the HTLV-1-infected and uninfected groups.<bold>Conclusions: </bold>Patients infected with HTLV-1 are more susceptible to TB. The epidemiological characteristics of HTLV-1/TB subjects and those infected with TB overlap.
- Subjects
BRAZIL; DISEASE incidence; HTLV-I; TUBERCULOSIS; RELATIVE medical risk; PUBLIC health; COMMUNICABLE diseases; DISEASE susceptibility; PATIENTS; TUBERCULOSIS complications; TUBERCULOSIS epidemiology; LONGITUDINAL method; RETROVIRUSES; DISEASE prevalence; RETROSPECTIVE studies; RNA virus infections; DISEASE complications
- Publication
BMC Infectious Diseases, 2016, p1
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-016-1428-z