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- Title
Update on hyperbaric oxygen therapy in burn treatment.
- Authors
Weitgasser, Laurenz; Ihra, Gerald; Schäfer, Bruno; Markstaller, Klaus; Radtke, Christine
- Abstract
Summary: Hyperbaric oxygen therapy (HBOT) has been shown to improve tissue hypoxia, neovascularization and ischemia reperfusion injury and reduce pathologic inflammation in various clinical settings and was proposed to be a game changer in treatment of burns. Improved and faster wound healing as well as a reduction of morbidity and mortality after thermal and concomitant carbon monoxide poisoning are expected. In defiance of the observed benefits for burn wounds and carbon monoxide poisoning in animal models and few randomized controlled trials there is an ongoing controversy regarding its use, indications and cost effectiveness. Furthermore, the use of HBOT, its indications and the evidence behind its efficiency are still widely unknown to most physicians involved in the treatment of burn patients. Therefore, a review of the up to date evidence-based literature was performed with a focus on available data of HBOT in burn care, to elaborate its use in acute thermal injury and carbon monoxide intoxication. Although beneficial effects of HBOT seem very likely insufficient evidence to support or disprove the routine use of HBOT in the treatment of burn care was found. Although difficult to carry out because of the high interindividual variability of burns and chronic wounds, the need for larger high-quality prospective randomized double-blinded controlled multicenter trials are necessary to be able to evaluate useful applications, expense and cost-efficiency of HBOT for burn care.
- Subjects
HYPERBARIC oxygenation; CARBON monoxide poisoning; REPERFUSION injury; CHRONIC wounds &; injuries; CARBON monoxide; RANDOMIZED controlled trials; BURN care units
- Publication
Wiener Klinische Wochenschrift, 2021, Vol 133, Issue 3/4, p137
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/s00508-019-01569-w