We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Clinical Practice Guideline for the prevention and early detection of breast and ovarian cancer in women from HBOC (hereditary breast and ovarian cancer) families.
- Authors
Singer, C.F.; Tea, M.K.; Pristauz, G.; Hubalek, M.; Rappaport, C.; Riedl, C.C.; Helbich, T.H.
- Abstract
An estimated 10 % of breast cancer cases exhibit a higher familial incidence, and functional mutations in BRCA (breast cancer-gene) 1 or 2 are responsible for the development of malignant tumors in approximately half of these cases. Women with a germline mutation in either of the two genes have a lifetime risk of up to 85 % to develop breast cancer, and of up to 60 % risk to develop ovarian cancer. This clinical practice guideline defines the individual and familial tumor constellations that represent an indication for BRCA germline testing. It also describes the therapeutic options (early detection programme vs prophylactic surgery) that arise from the result of a BRCA mutational analysis. This guideline further includes recommendations regarding the use of multigene panels and therapeutic aspects that arise from the selective use of poly ADP ribose polymerase (PARP) inhibitors in patients with known BRCA1 or 2 mutations. It replaces the previous version of the 'Clinical Practice Guideline for the Prevention and Early Detection of Breast- and Ovarian Cancer in women from HBOC (hereditary breast and ovarian cancer) families' which was published in 2012.
- Subjects
BREAST cancer; BREAST surgery; MAMMOGRAMS; HUMAN anatomy; INCURABLE diseases
- Publication
Wiener Klinische Wochenschrift, 2015, Vol 127, Issue 23/24, p981
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/s00508-015-0880-x