We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Accelerated Reepithelialization by Triterpenes: Proof of Concept in the Healing of Surgical Skin Lesions.
- Authors
Metelmann, Hans-Robert; Brandner, Johanna M.; Schumann, Hauke; Bross, Felix; Fimmers, Rolf; BFttger, Kerstin; Scheffler, armin; Podmelle, Fred
- Abstract
The acceleration of wound healing is a major surgical concern. A triterpene extract from birch bark (Betulae cortex) experimentally enhances keratinocyte differentiation in vitro and accelerates wound healing ex vivo. We conducted an open, blind-evaluated, controlled, prospective, randomized (1:1) phase II clinical trial in patients requiring split-thickness skin graft transplantation at two university hospitals in Germany. Donor sites on the upper legs were covered with a moist silicone-coated dressing. Oleogel-S10 ointment containing 10% birch bark extract was randomly applied to the distal or proximal half of the wound, with the other half serving as an intraindividual control, for 14 days after the skin graft surgery. The primary efficacy variable was faster reepithelialization as determined from macrophotographs by independent, blinded experts. Twenty-four patients were randomized and completed the trial. After the 14-day test period, the planned interim analysis revealed a highly significant (p < 0.0001) superiority of Oleogel-S10 in the primary efficacy variable and the trial was terminated early due to ethical concerns. The treatment side was also better reepithelialized and more similar to normal skin after 3 months. In conclusion, Oleogel-S10 significantly accelerated reepithelialization at split-thickness skin graft donor sites. Treatment with Oleogel-S10 was safe and well tolerated. © 2014 S. Karger AG, Basel
- Subjects
SKIN grafting; WOUND healing; OINTMENTS; BIRCH bark extract; PLANT extracts
- Publication
Skin Pharmacology & Physiology, 2015, Vol 28, Issue 1, p1
- ISSN
1660-5527
- Publication type
Article
- DOI
10.1159/000357501