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- Title
Ameliorating Effect of Lycopene and N-Acetylcysteine against Cisplatin-Induced Cardiac Injury in Rats.
- Authors
Elsayed, Asmaa; Elkomy, Ashraf; Alkafafy, Mohamed; Elkammar, Reda; Fadl, Sabreen Ezzat; Abdelhiee, Ehab Yahya; Abdeen, Ahmed; Youssef, Gehan; Shaheen, Hassan; Soliman, Ahmed; Aboubakr, Mohamed
- Abstract
Cisplatin (CP) is one of antineoplastic agents with a broad range of anticancer activities. This research investigated the possible protective effects of lycopene (LP) and N acetylcysteine (NAC) in rats against CP-induced cardiac toxicity. Seven groups of rats (n=7); control vehicle group was administered saline, LP (10 mg/kg, PO), NAC (150 mg/kg, PO), CP group (7.5 mg/kg, IP) on the 27th day of the experiment, LP-CP group, NAC-CP group, and LP-NAC-CP group. Following injection of CP, concentrations of cardiac biomarkers, lactate dehydrogenase (LDH), creatine kinase (CK) and creatine kinase MB (CK-MB) were increased in serum of the treated groups. In addition, CP resulted in a significant increase in malondialdehyde (MDA), as well as significant decreases in glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in rats' heart tissues. CP resulted in changes in cardiac histopathology and increased caspase-3 expression in cardiac tissues. Administration of LP and/or NAC ameliorated cardiac toxicity and apoptosis induced by CP, through their antioxidant properties.
- Subjects
LYCOPENE; HEART injuries; CARDIOTOXICITY; ACETYLCYSTEINE; CREATINE kinase; LACTATE dehydrogenase; METHYLENE blue
- Publication
Pakistan Veterinary Journal, 2022, Vol 42, Issue 1, p107
- ISSN
0253-8318
- Publication type
Article
- DOI
10.29261/pakvetj/2021.035