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- Title
ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells
- Authors
Fujimoto, Takahiro; Doi, Keiko; Koyanagi, Midori; Tsunoda, Toshiyuki; Takashima, Yasuo; Yoshida, Yasuhiro; Sasazuki, Takehiko; Shirasawa, Senji
- Abstract
Abstract: ZFAT (also known as ZNF406), originally identified as a candidate gene for autoimmune thyroid disease, encodes a zinc-finger protein, however, its function has not been elucidated. Here, we report that human ZFAT protein is expressed in peripheral B and T lymphocytes and a human acute T lymphoblastic leukaemia cell line, MOLT-4 cells. Intriguing is that mouse ZFAT expression in CD4+ lymphocytes is increased during blast formation. Furthermore, ZFAT-knockdown in MOLT-4 induces apoptosis via activation of caspases. These results suggested that ZFAT protein is a critical regulator involved in apoptosis and cell survival for immune-related cells.
- Subjects
AUTOIMMUNE diseases; APOPTOSIS prevention; ZINC-finger proteins; THYROID diseases; T cells; CELL lines; GENE expression; LABORATORY mice; GENETICS
- Publication
FEBS Letters, 2009, Vol 583, Issue 3, p568
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.12.063