We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cytokinesis is not controlled by calmodulin or myosin light chain kinase in the Caenorhabditis elegans early embryo
- Authors
Batchelder, Ellen L.; Thomas-Virnig, Christina L.; Hardin, Jeffery D.; White, John G.
- Abstract
Abstract: Furrow ingression in animal cell cytokinesis is controlled by phosphorylation of myosin II regulatory light chain (mRLC). In Caenorhabditis elegans embryos, Rho-dependent Kinase (RhoK) is involved in, but not absolutely required for, this phosphorylation. The calmodulin effector myosin light chain kinase (MLCK) can also phosphorylate mRLC and is widely regarded as a candidate for redundant function with RhoK. However, our results show that RNA mediated interference against C. elegans calmodulin and candidate MLCKs had no effect on cytokinesis in wild-type or RhoK mutant embryos, ruling out the calmodulin/MLCK pathway as the missing regulator of cytokinesis in the C. elegans early embryo.
- Subjects
CELL division; CYTOPLASM; VITAMIN B complex; CALMODULIN
- Publication
FEBS Letters, 2007, Vol 581, Issue 22, p4337
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.08.005