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- Title
Putting the clamps on membrane fusion: How complexin sets the stage for calcium-mediated exocytosis
- Authors
Melia, Thomas J.
- Abstract
Abstract: Three recent papers have addressed a long-standing question in exocytosis: how does a sudden calcium influx trigger a coordinated synchronous release in regulated exocytosis [Giraudo, C.G., Eng, W.S., Melia, T.J. and Rothman, J.E. (2006) A clamping mechanism involved in SNARE-dependent exocytosis. Science 313, 676–680; Schaub, J.R., Lu, X., Doneske, B., Shin, Y.K. and McNew, J.A. (2006) Hemifusion arrest by complexin is relieved by Ca2+–synaptotagmin I. Nat. Struct. Mol. Biol. 13, 748–750; Tang, J., Maximov, A., Shin, O.H., Dai, H., Rizo, J. and Sudhof, T.C. (2006) A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell 126, 1175–1187]? Using diverse approaches that include cell-free reconstitution of the membrane fusion machinery and in vivo manipulation of fusogenic proteins, these groups have established that the complexin proteins are fusion clamps. By arresting vesicle secretion just prior to fusion, complexin primes select vesicles for a fast, synchronous response to calcium.
- Subjects
EXOCYTOSIS; MEMBRANE fusion; CELL physiology; PROTEINS
- Publication
FEBS Letters, 2007, Vol 581, Issue 11, p2131
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.02.066