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- Title
Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR<sub>2</sub>
- Authors
Tsatsanis, Christos; Androulidaki, Ariadne; Dermitzaki, Erini; Charalampopoulos, Ioannis; Spiess, Joachim; Gravanis, Achille; Margioris, Andrew N.
- Abstract
Abstract: Macrophages undergo apoptosis as a mechanism of regulating their activation and the inflammatory reaction. Macrophages express the Corticotropin-Releasing Factor Receptor-2 (CRFR2) the endogenous agonists of which, the urocortins, are also present at the site of inflammation. We have found that urocortins induced macrophage apoptosis in a dose- and time-dependent manner via CRFR2. In contrast to lipopolysaccharide (LPS)-induced apoptosis, the pro-apoptosis pathway activated by urocortins involved the pro-apoptotic Bax and Bad proteins and not nitric oxide, JNK and p38MAPK characteristic of LPS. In conclusion, our data suggest that endogenous CRFR2 ligands exert an anti-inflammatory effect via induction of macrophage apoptosis.
- Subjects
MACROPHAGES; APOPTOSIS; KILLER cells; NITRIC oxide
- Publication
FEBS Letters, 2005, Vol 579, Issue 20, p4259
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.06.057