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- Title
The effect of aromatase inhibitor on controlled ovarian stimulation for oocyte cryopreservation in adolescent and young cancer patients.
- Authors
Suzuki, Reiko; Horage‐Okutsu, Yuki; Kawahara, Tai; Nakamura, Kentaro; Shiraishi, Eriko; Iwahata, Hideyuki; Suzuki‐Takahashi, Yuki; Sugishita, Yodo; Takae, Seido; Suzuki, Nao
- Abstract
Aim: To determine the impact of aromatase inhibitor (AI) use in oocyte cryopreservation among Japanese adolescent and young adult (AYA) cancer patients for fertility preservation, we evaluated the oocyte cryopreservation outcomes following AI therapy in combination with the follicular phase start (FPS) and random start (RS) protocols. Methods: This retrospective study included 81 cycles of controlled ovarian stimulation (COS) among 73 AYA patients with cancer who underwent oocyte cryopreservation to maintain fertility. The outcome measures were the total number of matured oocytes that were retrieved and cryopreserved, as well as their maturation rates. The AI (+) and AI (−) groups were compared using the RS and FPS protocols. Results: Our results showed that the combined use of AI and COS decreases serum E2 levels and maintains the number of retrieved and cryopreserved mature oocytes. We also confirmed the efficacy of the RS protocol, which was found to have comparable outcomes to that of the FPS protocol in both AI (+) and AI (−) groups. Conclusion: The combined use of AI and COS is beneficial for oocyte cryopreservation in patients with estrogen‐sensitive cancer, regardless of the menstrual cycle phase of COS initiation.
- Subjects
JAPAN; OOCYTE retrieval; SCIENTIFIC observation; MENSTRUAL cycle; OVUM; SERUM; RETROSPECTIVE studies; CANCER patients; COMPARATIVE studies; AROMATASE inhibitors; FERTILITY preservation; INDUCED ovulation; BREAST tumors; CRYOPRESERVATION of organs, tissues, etc.; PHARMACODYNAMICS; ADULTS; ADOLESCENCE
- Publication
Journal of Obstetrics & Gynaecology Research, 2023, Vol 49, Issue 3, p973
- ISSN
1341-8076
- Publication type
Article
- DOI
10.1111/jog.15535