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- Title
Synthesis of Axially Chiral Biaryls through Cobalt(II)‐Catalyzed Atroposelective C−H Arylation.
- Authors
Wu, Yong‐Jie; Wang, Zhen‐Kai; Jia, Zhen‐Sheng; Chen, Jia‐Hao; Huang, Fan‐Rui; Zhan, Bei‐Bei; Yao, Qi‐Jun; Shi, Bing‐Feng
- Abstract
Highly efficient synthesis of axially chiral biaryl amines through cobalt‐catalyzed atroposelective C−H arylation using easily accessible cobalt(II) salt and salicyloxazoline ligand has been reported. This methodology provides a straightforward and sustainable access to a broad range of enantioenriched biaryl‐2‐amines in good yields (up to 99 %) with excellent enantioselectivities (up to 99 % ee). The synthetic utility of the unprecedented method is highlighted by its scalability and diverse transformations.
- Subjects
ARYLATION; COBALT; DERACEMIZATION
- Publication
Angewandte Chemie, 2023, Vol 135, Issue 40, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202310004