We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Voltage‐Responsive Synthetic Cl<sup>−</sup>‐Channel Regulated by pH.
- Authors
Zheng, Shao‐Ping; Jiang, Ji‐Jun; Lee, Arie; Barboiu, Mihail
- Abstract
Transmembrane protein channels are an important inspiration for the design of artificial ion channels. Their dipolar structure helps overcome the high energy barrier to selectively translocate water and ions sharing one pathway, across the cell membrane. Herein, we report that the amino‐imidazole (Imu) amphiphiles self‐assemble via multiple H‐bonding to form stable artificial Cl−‐channels within lipid bilayers. The alignment of water/Cl− wires influences the conduction of ions, envisioned to diffuse along the hydrophilic pathways; at acidic pH, Cl−/H+ symport conducts along a partly protonated channel, while at basic pH, higher Cl−/OH− antiport translocate through a neutral channel configuration, which can be greatly activated by applying strong electric field. This voltage/pH regulated channel system represents an unexplored alternative for ion‐pumping along artificial ion‐channels, parallel to that of biology.
- Subjects
ION channels; MEMBRANE proteins; ACTIVATION energy; CELL membranes; ELECTRIC fields; BILAYER lipid membranes; CHLORIDE channels; VOLTAGE-gated ion channels
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 43, p19082
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202008393