We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Vitamin D and skeletal health in infancy and childhood.
- Authors
Moon, R.; Harvey, N.; Davies, J.; Cooper, C.
- Abstract
During growth, severe vitamin D deficiency in childhood can result in symptomatic hypocalcaemia and rickets. Despite the suggestion from some studies of a secular increase in the incidence of rickets, this observation may be driven more by changes in population demographics than a true alteration to age, sex and ethnicity-specific incidence rates; indeed, rickets remains uncommon overall and is rarely seen in fair-skinned children. Additionally, the impact of less severe vitamin D deficiency and insufficiency has received much interest in recent years, and in this review, we consider the evidence relating vitamin D status to fracture risk and bone mineral density (BMD) in childhood and adolescence. We conclude that there is insufficient evidence to support the suggestion that low serum 25-hydroxyvitamin D [25(OH)D] increases childhood fracture risk. Overall, the relationship between 25(OH)D and BMD is inconsistent across studies and across skeletal sites within the same study; however, there is evidence to suggest that vitamin D supplementation in children with the lowest levels of 25(OH)D might improve BMD. High-quality randomised trials are now required to confirm this benefit.
- Subjects
BONE fracture prevention; BONE physiology; OSTEOPOROSIS prevention; RICKETS prevention; THERAPEUTIC use of biochemical markers; DATABASES; EPIDEMIOLOGY; META-analysis; RESEARCH funding; VITAMIN D; VITAMIN D deficiency; SYSTEMATIC reviews; BONE density; CHILDREN
- Publication
Osteoporosis International, 2014, Vol 25, Issue 12, p2673
- ISSN
0937-941X
- Publication type
Article
- DOI
10.1007/s00198-014-2783-5