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- Title
A scoring system to predict the risk of atrial fibrillation in chronic lymphocytic leukemia.
- Authors
Visentin, Andrea; Deodato, Marina; Mauro, Francesca R.; Autore, Francesco; Reda, Gianluigi; Vitale, Candida; Molica, Stefano; Rigolin, Gian Matteo; Piazza, Francesco; Cesini, Laura; Tedeschi, Alessandra; Laurenti, Luca; Cassin, Ramona; Coscia, Marta; Cuneo, Antonio; Foà, Robin; Semenzato, Gianpietro; Trentin, Livio
- Abstract
Although ibrutinib is generally well tolerated, it has been associated with atrial fibrillation (AF) in 6-16% of cases.[1] Most CLL patients are elderly and suffer of several comorbidities[[2]] that may trigger AF regardless of ibrutinib. A prior history of AF was present in only 21 patients (2.4%) at CLL diagnosis, while, among the remaining 839 patients without a previous history of AF, 47 (5.6%) developed AF after a median follow-up of 9.4 years (Figure A). Although none of the 137 patients at score 0 developed AF, the 545 patients with score of 1-2 had a 10-year TTAF of 6%, while the risk for the 103 and 75 patients at score 3-4 and >=5 was 12% and 29%, respectively ( I p i < 0.001, Figure C). Our model was also able to identify patients at a higher risk of AF during ibrutinib; in fact, the 2-year risk of AF was 0%, 5%, 17%, and 40% for patients with score 0, 1-2, 3-4, and >=5, respectively ( I p i < 0.001, Figure F).
- Subjects
CHRONIC lymphocytic leukemia; ATRIAL fibrillation
- Publication
Hematological Oncology, 2019, Vol 37, Issue 4, p508
- ISSN
0278-0232
- Publication type
letter
- DOI
10.1002/hon.2655