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- Title
Comparison of the FACT-C, EORTC QLQ-CR38, and QLQ-CR29 quality of life questionnaires for patients with colorectal cancer: a literature review.
- Authors
Ganesh, Vithusha; Agarwal, Arnav; Popovic, Marko; Cella, David; McDonald, Rachel; Vuong, Sherlyn; Lam, Henry; Rowbottom, Leigha; Chan, Stephanie; Barakat, Tasneem; DeAngelis, Carlo; Borean, Michael; Chow, Edward; Bottomley, Andrew
- Abstract
<bold>Purpose: </bold>The purpose of this review was to compare the development, characteristics, validity, and reliability of three widely used quality of life (QOL) assessment tools used in colorectal cancer (CRC) patients: the Functional Assessment of Cancer Therapy-Colorectal (FACT-C), the European Organization for Research and Treatment of Cancer Quality of Life (EORTC) Quality of Life Questionnaire Colorectal Cancer Module (QLQ-CR38) and its successor, the QLQ-CR29.<bold>Methods: </bold>A literature search was conducted using Ovid EMBASE and EMBASE Classic (1996-2015 Week 39), Ovid MEDLINE and OLDMEDLINE (1996 September Week 4 2015), and the Cochrane Central Register of Controlled Trials (up to August 2015) to identify studies that discussed the FACT-C, EORTC QLQ-CR38, and QLQ-CR29 including, but not limited to, their development, characteristics, validity, and reliability.<bold>Results: </bold>The FACT-C consists of 36 items, presented on a 5-point Likert scale, in four domains of well-being (physical, emotional, social, and functional), and the Colorectal Cancer Subscale (CCS). The physical and social well-being scales showed reasonable internal consistency (Cronbach's alpha coefficient > 60) in all studied populations. The EORTC QLQ-CR38 (38 items) and the QLQ-CR29 (29 items) are implemented in conjunction with the core QLQ-C30 (30 items); all are presented in 4-point Likert scales. Seven scales in the QLQ-CR38 demonstrated good internal consistency (Cronbach's alpha coefficient > 0.70). In the QLQ-CR29, three scales had a Cronbach's alpha coefficient of less than 0.70.<bold>Conclusion: </bold>The FACT-C, QLQ-CR38, and QLQ-CR29 have been extensively validated. However, analysis of their characteristics, validity, and reliability suggest differing suitability in assessing QOL in specific clinical situations.
- Subjects
COLON cancer patients; QUALITY of life; QUESTIONNAIRES; COLON cancer treatment; CRONBACH'S alpha; MENTAL health; RECTUM tumors; COLON tumors; RESEARCH evaluation; SYSTEMATIC reviews; PSYCHOLOGY
- Publication
Supportive Care in Cancer, 2016, Vol 24, Issue 8, p3661
- ISSN
0941-4355
- Publication type
journal article
- DOI
10.1007/s00520-016-3270-7