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- Title
Antimicrobial Functionalization of Silicone-graft-poly(N -vinylimidazole) Catheters.
- Authors
Navarrete-Germán, Luis Enrique; Gómez-Lázaro, Belén; López-Saucedo, Felipe; Bucio, Emilio
- Abstract
In this work, we present the modification of a medical-grade silicone catheter with the N-vinylimidazole monomer using the grafting-from method at room temperature and induced by gamma rays. The catheters were modified by varying the monomer concentration (20–100 vol%) and the irradiation dose (20–100 kGy). Unlike the pristine material, the grafted poly(N-vinylimidazole) chains provided the catheter with hydrophilicity and pH response. This change allowed for the functionalization of the catheters to endow it with antimicrobial features. Thus, the quaternization of amines with iodomethane and bromoethane was performed, as well as the immobilization of silver and ampicillin. The inhibitory capacity of these materials, functionalized with antimicrobial agents, was challenged against Escherichia coli and Staphylococcus aureus strains, showing variable results, where loaded ampicillin was amply better at eliminating bacteria.
- Subjects
CATHETERS; GAMMA rays; ANTI-infective agents; STAPHYLOCOCCUS aureus; ESCHERICHIA coli; BREAST implants; ETHANES
- Publication
Molecules, 2024, Vol 29, Issue 10, p2225
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29102225