We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
3-Nitroatenolol: First Synthesis, Chiral Resolution and Enantiomers' Absolute Configuration.
- Authors
Sparaco, Rosa; Cinque, Pierfrancesco; Scognamiglio, Antonia; Corvino, Angela; Caliendo, Giuseppe; Fiorino, Ferdinando; Magli, Elisa; Perissutti, Elisa; Santagada, Vincenzo; Severino, Beatrice; Luciano, Paolo; Casertano, Marcello; Aiello, Anna; Martins Viegas, Gustavo Yuri; De Nucci, Gilberto; Frecentese, Francesco
- Abstract
4-Nitro and 7-nitro propranolol have been recently synthesized and characterized by us. (±)-4-NO2-propranolol has been shown to act as a selective antagonist of 6-nitrodopamine (6-ND) receptors in the right atrium of rats. As part of our follow-up to this study, herein, we describe the first synthesis of (±)-3-nitroatenolol as a probe to evaluate the potential nitration of atenolol by endothelium. Chiral chromatography was used to produce pure enantiomers. By using Riguera's method, which is based on the sign distribution of ΔδH, the absolute configuration of the secondary alcohol was determined.
- Subjects
RESOLUTION (Chemistry); RIGHT heart atrium; ENANTIOMERS; NITRATION; PROPRANOLOL; ENDOTHELIUM
- Publication
Molecules, 2024, Vol 29, Issue 7, p1598
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29071598