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- Title
Expression of inflammation-mediated cluster of genes as a new marker of canine mammary malignancy.
- Authors
Pawłowski, K.; Homa, A.; Bulkowska, M.; Majchrzak, K.; Motyl, T.; Król, M.
- Abstract
Because canine mammary tumours constitute a serious clinical problem and there are no good prognostic markers (only histopathological variables are used), the aim of the presented study was to find new malignancy markers as well as to identify intracellular pathways and biological processes characteristic for canine mammary malignancy. We compared gene expression of the most malignant mammary tumours (poorly differentiated cancers of the 3rd grade of malignancy) with less malignant tumours (well differentiated cancers of the 1st grade of malignancy). The results of our study indicated that in dogs the number of tumour-infiltrating myeloid cells or expression of myeloid-specific antigens by cancer cells is related to the cancer progression and may constitute a new marker of malignancy, however further studies in this field are required.
- Subjects
BIOMARKERS; DOG diseases; MAMMARY gland tumors; GENE expression in mammals; CANCER cells; CANCER invasiveness
- Publication
Veterinary Research Communications, 2013, Vol 37, Issue 2, p123
- ISSN
0165-7380
- Publication type
Article
- DOI
10.1007/s11259-013-9554-1