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- Title
Synthesis and structure of diamino derivatives of pyrano-[3,4-c]pyridines and 5,6,7,8-tetrahydroisoquinolines.
- Authors
Paronikyan, Ervand G.; Dashyan, Shushanik Sh.; Panosyan, Henrik A.; Ayvazyan, Armen G.; Tamazyan, Rafael A.
- Abstract
A new and effective method was developed for obtaining diamino derivatives of pyrano[3,4-c]pyridines and 5,6,7,8-tetrahydro-isoquinolines from 3-cyanopyridin-2(1H)-ones by Smiles rearrangement of the respective oxyacetamides. The structures of the synthesized compounds were studied by NMR spectroscopy and X-ray diffraction analysis. The results of X-ray diffraction studies revealed the presence of intermolecular hydrogen bonds in 6-(benzylamino)-3,3-dimethyl-8-(pyrrolidin-1-yl)-3,4-dihydro-1H-pyrano-[3,4-c]pyridine-5-carbonitrile. The obtained compounds were also tested for antimicrobial activity.
- Subjects
TETRAHYDROISOQUINOLINES; DIAMINO amino acids; PYRIDINE; AROMATIC compounds; MOLECULAR structure
- Publication
Chemistry of Heterocyclic Compounds, 2018, Vol 54, Issue 8, p804
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-018-2353-4