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- Title
Synthesis and inhibitory activity of 1,3-(adamantan-1(2)-yl)- imidazolidine-2,4,5-triones and 3,3'-(adamantan-1-yl)- bis(1-alkylimidazolidine-2,4,5-triones).
- Authors
D'yachenko, Vladimir; Burmistrov, Vladimir; Nishi, Kosuke; Kim, In-Hae; Butov, Gennady
- Abstract
A series of 1,3-(adamantan-1(2)-yl)imidazolidine-2,4,5-triones and 1,1'-(alkane-1,n-diyl)bis[3-(adamantan-1-yl)imidazolidine-2,4,5-triones] was synthesized via cyclization of 1,3-bis[adamantan-1(2)-ylureas] and 1,1'-(alkyl-1,n-diyl)bis[3-(adamantan-1-yl)ureas] with oxalyl chloride under mild conditions with high yields. All synthesized compounds were tested in vitro as inhibitors of soluble human epoxide hydrolase. A number of compounds have high inhibitory activity (IC 1.6-650 nM), which makes them promising inhibitors of soluble epoxide hydrolase.
- Subjects
ADAMANTANE; ALKANES; IMIDAZOLIDINES; HYDROLASES; EPOXY compounds
- Publication
Chemistry of Heterocyclic Compounds, 2017, Vol 53, Issue 10, p1080
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-017-2174-x