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- Title
Clinical Utility of Bland Embolization Using Microspheres for Painful Malignant Musculoskeletal Tumors.
- Authors
JUNICHI TANIGUCHI; HARUYUKI TAKAKI; HIROSHI KODAMA; TAKAYUKI KAWAGUCHI; MOTONORI TAKAHAGI; ATSUSHI OGASAWARA; YASUKAZU KAKO; KAORU KOBAYASHI; TETSUYA MINAMI; HIROYUKI FUTANI; KOICHIRO YAMAKADO
- Abstract
Background/Aim: To evaluate retrospectively whether bland embolization using microspheres is safe and useful for relieving pain in patients with painful malignant musculoskeletal (MSK) tumors. Patients and Methods: Bland embolization using microspheres was performed for 20 patients (11 women/9 men) with a median age of 69 years (range=40-89 years) who had 22 painful malignant MSK tumors. The maximum tumor diameters were 2.4-13.8 cm (median, 7.5 cm). Pain was evaluated using the visual analog scale. A decrease of this score by 2 or more after embolization was defined as clinically effective pain relief. Adverse events (AEs) were evaluated using CTCAE v5.0. Objective response, disease control rates, and overall survival were also evaluated. Results: Effective pain relief was achieved in 18 patients (90.0%, 18/20). Grade-3 AEs developed in four patients (20.0%, 4/20): skin ulcer (n=2), skin ulcer and pain (n=1), and muscle weakness with dysesthesia (n=1). No grade-4 or grade-5 AEs developed. Objective response and disease control rates were 26.7% (4/15) and 86.7% (13/15), respectively. The 1-year survival rate was 43.8%, with median survival of 9.2 months (range=0.5-41.0 months). Conclusion: Although the survival benefit is equivocal, bland embolization is acceptably safe and useful for relieving pain by controlling tumor growth in patients with painful malignant MSK tumors.
- Subjects
MICROSPHERES; ANALGESIA; MUSCULOSKELETAL system diseases; TUMOR treatment; THERAPEUTIC embolization
- Publication
In Vivo, 2023, Vol 37, Issue 4, p1816
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.13272