We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Octylphenol Reduces the Expressions of Steroidogenic Enzymes and Testosterone Production in Mouse Testis.
- Authors
Suel-Kee Kim; Jong-Hoon Kim; Ho-Joon Lee; Yong-Dal Yoon
- Abstract
This article discusses the alteration of steroidogenesis in the testis of juvenile and adult mice after exposure to octylphenol. Testosterone concentration was measured by radioimmunoassay and the expressions of the testicular genes were determined by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR) analysis. The authors found reduced serum testosterone and down-regulated expressions of the mRNAs for steroidogenic acute regulatory protein (StAR), a cholesterol transport gene were accompanied by diminished lipid content in Leydig cells. They concluded that exposure to octylphenol may adversely affect spermatogenesis and the normal development of the testis.
- Subjects
PHYSIOLOGICAL effects of phenols; MICE; TESTIS; IMMUNOHISTOCHEMISTRY; MALE reproductive organs; CHOLESTEROL; LEYDIG cells; STEROID hormones; REGULATION of spermatogenesis; GENE expression; RADIOIMMUNOASSAY; PHYSIOLOGY
- Publication
Environmental Toxicology, 2007, Vol 22, Issue 5, p449
- ISSN
1520-4081
- Publication type
Article
- DOI
10.1002/tox.20280