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- Title
氟脱氧葡萄糖PET/CT在原发性胃肠道淋巴瘤化疗中期 预后评估中的价值.
- Authors
郑立春; 张欢; 顾程; 刘丽云; 张晓明; 欧阳向柳
- Abstract
Objective To evaluate the prognostic value of 18F-fluorodeoxyglucose (18F-FDG) PET/CT Deauville score and the change in the maximum standardized uptake value (ΔSUVmax) during interim chemotherapy for primary gastrointestinal lymphoma (PGIL) . Methods 18F-FDG PET/CT results of fifty-four patients with PGIL undergoing interim chemotherapy in Tangshan Gongren Hospital from January 2012 to December 2019 were collected for this retrospective analysis. A receiver operating characteristic (ROC) curve was used to estimate the optimal cutoff value of the ΔSUVmax,ΔSUVmax%,and Deauville score. Kaplan-Meier curve and Cox regression analysis were used to determine the prognostic value of these indictors. Results There was disease progression in twenty-one of the fifty-four patients, and thirty-three did not experience disease progression. The difference of means of the ΔSUVmax between the two groups was statistically significant (5.37±4.19 vs 8.14±5.29,P < 0.05) . The difference of medians of the ΔSUVmax% between the two groups was statistically significant (44.12% vs 73.53%,P < 0.05) . The AUC of the ROC curve for the ΔSUVmax and ΔSUVmax% were 0.651 (P = 0.064) and 0.775 (P = 0.001), respectively. The cutoff of the ΔSUVmax and ΔSUVmax% were 10.35 and 64.86%,respectively. Kaplan-Meier analysis showed that the difference in the three-year PFS between the lower and higher ΔSUVmax(52.4% vs 91.7%) and between the lower and higher ΔSUVmax% (36.4% vs 78.1%) were statistically significant (P < 0.01) . The difference in the three-year PFS between Deauville score<4 (PET negative) and Deauville score≥4 (PET positive) was statistically significant (92.0% vs 34.5%,P < 0.01) . Deauville score was negatively correlated with the ΔSUVmax and ΔSUVmax%. The multivariate Cox analysis results showed that Deauville score and ΔSUVmax were significant prognostic factors for PFS. Conclusion Deauville score and the ΔSUVmax have high prognostic value during interim chemotherapy for PGIL. Deauville score and the ΔSUVmax were the significant prognostic factors for PFS.
- Subjects
RECEIVER operating characteristic curves; PROGNOSIS; REFERENCE values; DISEASE progression; REGRESSION analysis
- Publication
Journal of China Medical University, 2023, Vol 52, Issue 9, p823
- ISSN
0258-4646
- Publication type
Article
- DOI
10.12007/j.issn.0258‐4646.2023.09.009