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- Title
Observational Study of Repeat Immunoadsorption (RIA) in Post-COVID ME/CFS Patients with Elevated ß2-Adrenergic Receptor Autoantibodies—An Interim Report.
- Authors
Stein, Elisa; Heindrich, Cornelia; Wittke, Kirsten; Kedor, Claudia; Kim, Laura; Freitag, Helma; Krüger, Anne; Tölle, Markus; Scheibenbogen, Carmen
- Abstract
There is increasing evidence for an autoimmune aetiology in post-infectious Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). SARS-CoV-2 has now become the main trigger for ME/CFS. We have already conducted two small proof-of-concept studies on IgG depletion by immunoadsorption (IA) in post-infectious ME/CFS, which showed efficacy in most patients. This observational study aims to evaluate the efficacy of IA in patients with post-COVID-19 ME/CFS. The primary objective was to assess the improvement in functional ability. Due to the urgency of finding therapies for post-COVID-Syndrome (PCS), we report here the interim results of the first ten patients, with seven responders defined by an increase of between 10 and 35 points in the Short-Form 36 Physical Function (SF36-PF) at week four after IA. The results of this observational study will provide the basis for patient selection for a randomised controlled trial (RCT), including sham apheresis, and for an RCT combining IA with B-cell depletion therapy. Trial registration number: NCT05629988.
- Subjects
IMMUNOADSORPTION; COVID-19; COVID-19 pandemic; AUTOANTIBODIES; CHRONIC fatigue syndrome
- Publication
Journal of Clinical Medicine, 2023, Vol 12, Issue 19, p6428
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm12196428