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- Title
The Prognosis of Baseline Mitral Regurgitation in Patients with Transcatheter Aortic Valve Implantation.
- Authors
Zhang, Juqian; Bisson, Arnaud; Boumhidi, Jad; Herbert, Julien; Saint Etienne, Christophe; Bernard, Anne; Lip, Gregory Y.H.; Fauchier, Laurent
- Abstract
Mitral regurgitation (MR) is the most common valvular lesion in transcatheter aortic valve implantation (TAVI) recipients. This study aims to assess the long-term prognostic impact of baseline MR in TAVI patients. Methods: Adult patients who underwent TAVI were identified in the French National Hospital Discharge Database. All-cause and cardiovascular mortality, stroke, and rehospitalization with heart failure (HF) were compared in TAVI patients with and without baseline MR and tricuspid regurgitation (TR), respectively; the associations of MR and TR with the outcomes were assessed by Cox regression. Results: Baseline MR was identified in 8240 TAVI patients. Patients with baseline MR have higher yearly incidence of all-cause mortality (HR: 1.192, 95% confidence interval CI: 1.125–1.263), cardiovascular mortality (HR: 1.313, 95%CI: 1.210–1.425), and rehospitalization for heart failure (HF) (HR: 1.411, 95%CI: 1.340–1.486) compared to those without, except for stroke rate (HR: 0.988, 95%CI: 0.868–1.124). Neither baseline MR nor TR was an independent risk predictor for all-cause mortality or cardiovascular mortality in TAVI patients. Baseline MR was independently associated with rehospitalization for HF in TAVI patients. Conclusions: Baseline MR and TR were associated with increased all-cause and cardiovascular mortality post-TAVI, however, neither of them was independent predictor for all-cause or cardiovascular mortality.
- Subjects
HEART valve prosthesis implantation; MITRAL valve insufficiency; MORTALITY; HEART failure; HOSPITAL admission &; discharge
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 17, p3974
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10173974