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- Title
Autoantibodies to Vasoregulative G-Protein-Coupled Receptors Correlate with Symptom Severity, Autonomic Dysfunction and Disability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.
- Authors
Freitag, Helma; Szklarski, Marvin; Lorenz, Sebastian; Sotzny, Franziska; Bauer, Sandra; Philippe, Aurélie; Kedor, Claudia; Grabowski, Patricia; Lange, Tanja; Riemekasten, Gabriela; Heidecke, Harald; Scheibenbogen, Carmen
- Abstract
Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an acquired complex disease with patients suffering from the cardinal symptoms of fatigue, post-exertional malaise (PEM), cognitive impairment, pain and autonomous dysfunction. ME/CFS is triggered by an infection in the majority of patients. Initial evidence for a potential role of natural regulatory autoantibodies (AAB) to beta-adrenergic (AdR) and muscarinic acetylcholine receptors (M-AChR) in ME/CFS patients comes from a few studies. Methods: Here, we analyzed the correlations of symptom severity with levels of AAB to vasoregulative AdR, AChR and Endothelin-1 type A and B (ETA/B) and Angiotensin II type 1 (AT1) receptor in a Berlin cohort of ME/CFS patients (n = 116) by ELISA. The severity of disease, symptoms and autonomic dysfunction were assessed by questionnaires. Results: We found levels of most AABs significantly correlated with key symptoms of fatigue and muscle pain in patients with infection-triggered onset. The severity of cognitive impairment correlated with AT1-R- and ETA-R-AAB and severity of gastrointestinal symptoms with alpha1/2-AdR-AAB. In contrast, the patients with non-infection-triggered ME/CFS showed fewer and other correlations. Conclusion: Correlations of specific AAB against G-protein-coupled receptors (GPCR) with symptoms provide evidence for a role of these AAB or respective receptor pathways in disease pathomechanism.
- Subjects
BERLIN (Germany); CHRONIC fatigue syndrome; MUSCARINIC acetylcholine receptors; AUTOANTIBODIES; DYSAUTONOMIA; SYMPTOMS; COGNITION disorders
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 16, p3675
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10163675