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- Title
A Retrospective Comparison of DLI and gDLI for Post-Transplant Treatment.
- Authors
Lamure, Sylvain; Paul, Franciane; Gagez, Anne-Laure; Delage, Jérémy; Vincent, Laure; Fegueux, Nathalie; Sirvent, Anne; Gehlkopf, Eve; Veyrune, Jean Luc; Yang, Lu Zhao; Kanouni, Tarik; Cacheux, Valère; Moreaux, Jérôme; Bonafoux, Beatrice; Cartron, Guillaume; De Vos, John; Ceballos, Patrice
- Abstract
Donor lymphocyte infusion (DLI) is used to prevent or treat haematological malignancies relapse after allogeneic stem cell transplantation (allo-SCT). Recombinant human granulocyte colony-stimulated factor primed DLI (gDLI) is derived from frozen aliquots of the peripheral blood stem cell collection. We compared the efficacy and safety of gDLI and classical DLI after allo-SCT. We excluded haploidentical allo-SCT. Initial diseases were acute myeloblastic leukaemia (n = 45), myeloma (n = 38), acute lymphoblastic leukaemia (n = 20), non-Hodgkin lymphoma (n = 10), myelodysplasia (n = 8), Hodgkin lymphoma (n = 8), chronic lymphocytic leukaemia (n = 7), chronic myeloid leukaemia (n = 2) and osteomyelofibrosis (n = 1). Indications for DLI were relapse (n = 96) or pre-emptive treatment (n = 43). Sixty-eight patients had classical DLI and 71 had gDLI. The response rate was 38.2%, the 5-year progression-free survival (PFS) rate was 38% (29–48) and the 5-year overall survival (OS) rate was 37% (29–47). Graft versus host disease rate was 46.7% and 10.1% of patients died from toxicity. There were no differences between classical DLI and gDLI in terms of response (p = 0.28), 5-year PFS (p = 0.90), 5-year OS (p. 0.50), GvHD (p = 0.86), treated GvHD (p = 0.81) and cause of mortality (p. 0.14). In conclusion, this study points out no major effectiveness or toxicity of gDLI compared to classical DLI.
- Subjects
ACUTE myeloid leukemia; LYMPHOBLASTIC leukemia; LYMPHOCYTIC leukemia; CHRONIC myeloid leukemia; CHRONIC leukemia
- Publication
Journal of Clinical Medicine, 2020, Vol 9, Issue 7, p2204
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm9072204