We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ACE-2 Downregulation and Incidence of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Infection.
- Authors
Weir, Robin A P; Glen, Claire; McDowell, Kirsty
- Abstract
If incidence and hospitalization rate is reduced, this could inform a paradigm shift in focus from ACE-2 amelioration to antagonism in the prevention/limitation of future ACE-2 mediated viral infections including SARS-CoV-2. 2 Dublin et al.'s study therefore infers, indirectly, that chronically increased ACE-2 does not predispose to SARS-CoV-2 infection or severity despite its high affinity for ACE-2. 1,2 The effect of chronically downregulated ACE-2 on susceptibility to SARS-CoV-2 is unknown.
- Subjects
SARS-CoV-2; COVID-19; DOWNREGULATION; ANGIOTENSIN II; ACE inhibitors; ANGIOTENSIN converting enzyme; ANGIOTENSIN-receptor blockers; DIABETIC nephropathies
- Publication
American Journal of Hypertension, 2021, Vol 34, Issue 4, p426
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1093/ajh/hpaa191