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- Title
Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205.
- Authors
D’Apice, Luciana; Costa, Valerio; Sartorius, Rossella; Trovato, Maria; Aprile, Marianna; De Berardinis, Piergiuseppe; D'Apice, Luciana
- Abstract
The filamentous bacteriophage fd, codisplaying antigenic determinants and a single chain antibody fragment directed against the dendritic cell receptor DEC-205, is a promising vaccine candidate for its safety and its ability to elicit innate and adaptive immune response in absence of adjuvants. By using a system vaccinology approach based on RNA-Sequencing (RNA-Seq) analysis, we describe a relevant gene modulation in dendritic cells pulsed with anti-DEC-205 bacteriophages fd. RNA-Seq data analysis indicates that the bacteriophage fd virions are sensed as a pathogen by dendritic cells; they activate the danger receptors that trigger an innate immune response and thus confer a strong adjuvanticity that is needed to obtain a long-lasting adaptive immune response.
- Subjects
FILAMENTOUS bacteriophages; BACTERIOPHAGE fd; IMMUNITY; BACTERIOPHAGES; IMMUNOLOGY; PROTEIN metabolism; IMMUNE system physiology; METABOLISM in viruses; ANIMAL experimentation; ANTIGENS; CELL receptors; CLUSTER analysis (Statistics); DENDRITIC cells; GENE expression; GENETIC engineering; IMMUNOGLOBULINS; IMMUNOLOGY technique; MICE; PEPTIDES; PROTEINS; RECOMBINANT proteins; T cells; VIRUSES; GENE expression profiling; CHEMICAL inhibitors
- Publication
Journal of Immunology Research, 2015, Vol 2015, p1
- ISSN
2314-8861
- Publication type
journal article
- DOI
10.1155/2015/585078