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- Title
Expression of TNF-α and IL-1β in Splenic Dendritic Cells and Their Serum Levels in Mouse Sparganosis.
- Authors
Hyun-Jong Yang
- Abstract
Sparganosis is a tissue invading helminthiasis infecting intermediate hosts, including humans. Strong immune responses are expected to occur in early phases of infection. Thus, we investigated cytokine expressions in splenic dendritic cells and in sera after experimental infection of mice. In splenic dendritic cells, TNF-α and IL-1β expression peaked at week 1 and week 3 post-infection (PI), respectively, and also early phase (week 2 PI) depressed cytokine expression was noticed. Serum IL-1β concentration increased significantly at week 2 PI and peaked at week 6 PI, and that of TNF-α peaked at week 6 PI. These results showed that pro-inflammatory cytokines, TNF-α and IL-1β, are chronologically regulated in mouse sparganosis.
- Subjects
GENE expression; TUMOR necrosis factors; SPARGANIUM; HELMINTHIASIS; IMMUNE response; CYTOKINES; DENDRITIC cells; MICE; INFLAMMATION
- Publication
Korean Journal of Parasitology, 2011, Vol 49, Issue 2, p191
- ISSN
0023-4001
- Publication type
Article
- DOI
10.3347/kjp.2011.49.2.191