We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Radioiodination and biological evaluation of irbesartan as a tracer for cardiac imaging.
- Authors
Sanad, M. H.; Marzook, F. A.; Abd-Elhaliem, S. M.
- Abstract
Irbesartan was labeled using 125I or 131I with N-bromosuccinimide (NBS) as an oxidizing agent. A lot of operators such as, quantity of substrate, the quantity of oxidizing agent, reaction temperature, reaction time, and pH of reaction medium were studied to optimize high radiochemical yield of [125I]IodoIrbesartan ([125I]Irb.). The preclinical evaluation of IodoIrbesartan in experimental mice indicated high accumulation in target organ of heart with a high heart/blood ratio of 12.85 at 30 min post-injection. This study indicates the suitability of [125I]IodoIrbesartan ([125I]Irb.) for cardiac imaging.
- Subjects
CARDIAC imaging; RADIOIODINATION; IRBESARTAN; OXIDIZING agents; SCINTILLATION cameras; RADIOACTIVE tracers
- Publication
Radiochimica Acta, 2021, Vol 109, Issue 1, p41
- ISSN
0033-8230
- Publication type
Article
- DOI
10.1515/ract-2020-0025