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- Title
Physiological and genetic characteristics of black-boned sheep ( Ovis aries).
- Authors
Deng, W. D.; Yang, S. L.; Huo, Y. Q.; Gou, X.; Shi, X. W.; Mao, H. M.
- Abstract
Here we report for the first time the discovery of sheep that have black bones and black muscles. The spectral pattern of pigment extracted from tissues of these black-boned sheep is similar to that of black-boned Chinese silky fowl. Additionally, black-boned sheep have significantly higher plasma colour, tyrosinase activity and kidney function than normal sheep. Synonymous nucleotide substitutions in the tyrosinase ( TYR) and melanocortin 1 receptor ( MC1R) genes were detected in black-boned sheep when compared with the corresponding sequences in normal sheep. In addition, a missense mutation (215T>C) in exon 2 of tyrosinase-related protein 1 ( TYRP1) was detected in black-boned sheep, and this resulted in a putative valine-to-alanine substitution at codon 68 (Val68Ala).
- Subjects
SHEEP breeds; ANIMAL genetics research; ANIMAL pigments; BLOOD pigments; PHENOL oxidase; SUBSTITUTION of heirs; HEREDITY; ANIMAL mutation breeding
- Publication
Animal Genetics, 2006, Vol 37, Issue 6, p586
- ISSN
0268-9146
- Publication type
Article
- DOI
10.1111/j.1365-2052.2006.01530.x