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- Title
Introducing Critical Genes in Response to Photodynamic Therapy: A Network Analysis.
- Authors
Mansouri, Vahid; Arjmand, Babak; Hamzeloo-Moghadam, Maryam; Tavirani, Mostafa Rezaei; Razzaghi, Zahra; Ahmadzadeh, Alireza; Nejad, Mohammad Rostami; Robati, Reza Mohamoud
- Abstract
Introduction: Photodynamic therapy (PDT) is applied as an efficient method for preventing the progress of cancers. Light and a photosensitive compound which is known as photosensitizer (PS) are the main parts of PDT. In the present study, molecular events after using PDT in the presence of a super lethal dose of a PS were assessed via protein-protein interaction (PPI) analysis. Methods: Data were extracted from Gene Expression Omnibus (GEO). The gene expression profiles of the treated human Sk-Cha1 cells via PDT were compared with the control cells. Expressed change analysis and PPI network analysis were administrated via Cytoscape software v 3.7.2 to find the critical differentially expressed genes (DEGs). Regulatory relationships between the central DEGs were evaluated and the highlighted genes were identified. Results: The significant amounts of gene expression values were grouped and a few DEGs characterized by tremendously expressed values were identified. EGFR, CANX, HSPA5, MYC, JUN, ITGB1, APP, and CDH1 were highlighted as hub-bottleneck DEGs. EGFR, CDH1, and JUN appeared as a set of SEGs, which play a crucial role in response to PDT in the treated Sk-Cha1 cells. Conclusion: In conclusion, regulatory relationships between EGFR, CDH1, and JUN, which have an effect on the regulation of cellular survival, differentiation, and proliferation, were highlighted in the present investigation.
- Subjects
PHOTODYNAMIC therapy; GENE expression; GENES; GENE expression profiling; PROTEIN-protein interactions
- Publication
Journal of Lasers in Medical Sciences, 2023, Vol 14, p1
- ISSN
2008-9783
- Publication type
Article
- DOI
10.34172/jlms.2023.25