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- Title
Drug-resistant hypertensive patients responding to multielectrode renal denervation exhibit improved heart rate dynamics and reduced arrhythmia burden.
- Authors
Tsioufis, C; Papademetriou, V; Tsiachris, D; Dimitriadis, K; Kasiakogias, A; Kordalis, A; Antonakis, V; Kefala, A; Thomopoulos, C; Kallikazaros, I; Lau, E O-Y; Stefanadis, C
- Abstract
Transluminal renal sympathetic denervation (RDN) reduces blood pressure (BP) in patients with drug-resistant uncontrolled hypertension. We assessed the effect of RDN on heart rate, supraventricular and ventricular ectopic activity and indexes of heart rate variability in 14 patients with drug-resistant uncontrolled hypertension who were all responders to RDN (defined as a reduction in office systolic BP ⩾10 mm Hg) at baseline and at 1 and 6 months after the procedure using the multielectrode EnligHTN ablation catheter (St Jude Medical). Office and 24-h systolic and diastolic BP were significantly reduced both at 1 and 6 months after RDN and all patients were office BP responders. There was a trend toward office heart rate reduction (by 6.9 b.p.m., P=0.064) at 1 month and a significant reduction by 10 b.p.m. (P=0.004) at 6 months. Mean 24-h Holter monitoring heart rate was reduced by 6.7 b.p.m. (P=0.022) at 1 month and by 5.3 b.p.m. (P=0.010) at 6 months after RDN. The total number of premature supraventricular and ventricular contractions was significantly decreased and time- and frequency- domain indexes were increased both at 1 and at 6 months after RDN (P<0.05 for both cases). Apart from the substantial BP lowering, RDN results in significant reduction of mean heart rate and arrhythmia burden, restoring autonomic balance in responder patients with drug-resistant uncontrolled hypertension.
- Subjects
DRUG resistance; REGULATION of blood pressure; HYPERTENSION; ARRHYTHMIA; MEDICAL care
- Publication
Journal of Human Hypertension, 2014, Vol 28, Issue 10, p587
- ISSN
0950-9240
- Publication type
Article
- DOI
10.1038/jhh.2014.14