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- Title
ANTI-PYRETIC ACTIVITY OF PILIOSTIGMA THONNINGII.
- Authors
Goli, Venkateshwarlu; Dinakaran, Sathis Kumar; Macharla, Sravan Prasad; Bhasker, K. Vijay; Gowrishankar, N. L.; Bhaskar, J.
- Abstract
The present study was carried out to investigate the anti-pyretic activity of petroleum ether, alcoholic and aqueous extracts of Piliostigma thonningii, leaves using experimental animal models. The extracts were screened for alkaloids, steroids, proteins, flavanoids, saponins, mucilage, carbohydrates, tannins, fats and oils. Anti-pyretic activity was evaluated using the brewer's yeast-induced pyrexia in rats. The extracts in dose levels of 50,100 and 200 mg/kg orally were used for anti-pyretic studies. The ethanol and aqueous extracts of leaves of Piliostigma thonningii produced significant (P<0.05) anti-pyretic activity. The three extracts has shown a good anti-pyretic effect (P<0.05) with all the doses used when compared to the control group. The results obtained indicate that the crude leaf extracts of Piliostigma thonningii possess potent anti-pyretic activity by supporting the folkloric usage of the plant to treat various diseases.
- Subjects
ANTIPYRETICS; FEVER; ANIMAL models in research; PLANT extracts; ETHANOL; CONTROL groups
- Publication
International Journal of Pharmacology & Biological Sciences, 2011, Vol 5, Issue 3, p43
- ISSN
0973-6808
- Publication type
Article