We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Selective functionalization: Shields for small molecules.
- Authors
Silverman, Scott K.
- Abstract
The article discusses a study which describes an approach in which nucleic acid aptamers are employed as noncovalent protecting groups in the form of aptameric protective groups (APGs) to shield small molecules. It states that the motivation for developing APG is the difficulty in differentiating chemically equivalent (or nearly so) functional groups of complex natural products using small-molecule reagents. It says that previously identified RNA aptamers known to bind neomycin B were exploited to identify the appropriate macromolecule that will serve as noncovalent protecting group.
- Subjects
MOLECULES; NUCLEIC acids; APTAMERS; NEOMYCIN; FUNCTIONAL groups; MACROMOLECULES; REACTIVITY (Chemistry); COVALENT bonds; CHEMICAL reagents
- Publication
Nature Chemistry, 2012, Vol 4, Issue 10, p774
- ISSN
1755-4330
- Publication type
Article
- DOI
10.1038/nchem.1468