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- Title
Calcium Carbide: From Elemental Carbon to Isotope-Economic Synthesis of <sup>13</sup>C<sub>2</sub>-Labeled Heterocycles.
- Authors
Ledovskaya, Maria S.; Voronin, Vladimir V.; Valov, Nikita R.; Samoylenko, Dmitriy E.
- Abstract
13C-Carbon is the most available source of carbon-13. It is a relatively inexpensive solid material, which can be easily converted to calcium carbide-13C2. In current work, Ca13C2 was used for in situ generation of 13C2-acetylene in 1,3-dipolar cycloaddition and [4+2] cycloaddition reaction. For the first time, 1H-1,2,3-triazoles-4,5-13C2 and isoxazoles-4,5-13C2 were synthesized using calcium carbide-13C2. A Diels-Alder type cycloaddition of 3,6-di(pyridin-2-yl)-1,2,4,5-tetrazine and Ca 13C2 was investigated, and the best way for the synthesis of 3,6-di(pyridin-2-yl)pyridazine-4,5-13C2 was proposed for the first time. Here we perform a detailled description of NMR spectra of 13C2-labeled triazoles, isoxazoles and 3,6-di(pyridin-2-yl)pyridazine.
- Subjects
CALCIUM carbide; HETEROCYCLIC compounds; RING formation (Chemistry); ISOXAZOLES; SUSTAINABLE chemistry; PYRIDAZINES
- Publication
Chinese Journal of Chemistry, 2023, Vol 41, Issue 21, p2810
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.202300261