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- Title
Facile Synthesis of Amino Acid Decorated Water‐Soluble Fullerene Derivatives with Anti‐influenza Activity<sup>†</sup>.
- Authors
Bolshakova, Valeriya S.; Sinegubova, Ekaterina O.; Esaulkova, Yana L.; Peregudov, Alexander S.; Khakina, Ekaterina A.; Slesarenko, Nikita A.; Shestakov, Alexander F.; Zarubaev, Vladimir V.; Troshin, Pavel A.; Kraevaya, Olga A.
- Abstract
Comprehensive Summary: Herein, we present a facile synthesis of amide‐type water‐soluble fullerene derivatives decorated with five residues of amino acids. As compared to the previously developed approaches, the proposed method enables usage of a broad range of amino acids, including those unstable under Friedel‐Crafts reaction conditions. Furthermore, it is fully tolerant to the nature of the sixth addend X in C60R5X precursor compounds and allows one to obtain fullerene derivatives with X=Cl, H, alkyl. The synthesized amide‐type water‐soluble fullerene derivatives demonstrated promising antiviral activities against rimantadine‐resistant influenza А/Puerto Rico/8/34 (Н1N1) virus in vitro.
- Subjects
PUERTO Rico; FULLERENE derivatives; AMINO acid synthesis; QUINAZOLINONES; FRIEDEL-Crafts reaction; AMINO acid residues; AMINO acids
- Publication
Chinese Journal of Chemistry, 2023, Vol 41, Issue 15, p1803
- ISSN
1001-604X
- Publication type
Article
- DOI
10.1002/cjoc.202300050