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- Title
Expression of thymidine phosphorylase and vascular endothelial cell growth factor in human head and neck squamous cell carcinoma and their different characteristics.
- Authors
Fukuiwa, Tatsuya; Takebayashi, Yuji; Akiba, Suminori; Matsuzaki, Tsutomu; Hanamure, Yutaka; Miyadera, Kazutaka; Yamada, Yuji; Akiyama, Shin-ichi; Fukuiwa, T; Takebayashi, Y; Akiba, S; Matsuzaki, T; Hanamure, Y; Miyadera, K; Yamada, Y; Akiyama, S
- Abstract
<bold>Background: </bold>Thymidine phosphorylase (dThdPase) is identical to platelet-derived endothelial cell growth factor (PD-ECGF). dThdPase is known to promote the development of new blood vessels, which are fundamental to tumor growth and metastasis. Vascular endothelial growth factor (VEGF) is a 34-42 kilodalton (kD) protein that induces both angiogenesis and vascular permeability. Proliferating cell nuclear antigen (PCNA) is a 36 kD nuclear protein, and its expression is associated with DNA synthesis and cell proliferation.<bold>Methods: </bold>The authors investigated the correlations of dThdPase and VEGF with the growth of head and neck squamous cell carcinoma (HNSCC) in 95 patients by examining PCNA expression as a marker of tumor proliferation. They also retrospectively examined the expression of dThdPase in primary HNSCC and its association with angiogenesis and clinicopathologic findings.<bold>Results: </bold>Microvessel count was significantly correlated with the expression of VEGF (P = 0.046) but not with dThdPase expression. The expression of PCNA was significantly correlated with dThdPase (P < 0.001) but not VEGF expression. A significant correlation was found between VEGF and dThdPase expression (P = 0.003). Neither dThdPase nor VEGF correlated with clinicopathologic findings, except for the correlation between tumor location and VEGF expression (P 0.020).<bold>Conclusions: </bold>These findings suggest that VEGF is involved in angiogenesis in HNSCC. dThdPase may have effects on tumor growth other than angiogenic activity in HNSCC.
- Publication
Cancer (0008543X), 1999, Vol 85, Issue 4, p960
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/(SICI)1097-0142(19990215)85:4<960::AID-CNCR26>3.0.CO;2-P