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- Title
4′-Hydroxyflavanone suppresses activation of sterol regulatory element-binding proteins and de novo lipid synthesis
- Authors
Miyata, Shingo; Inoue, Jun; Shimizu, Makoto; Sato, Ryuichiro
- Abstract
Abstract: Sterol regulatory element-binding proteins (SREBPs) are major transcription factors that regulate the expression of genes involved in fatty acid and cholesterol biosynthesis. Here we show that 4′-hydroxyflavanone (4′-HF) impairs the fatty acid synthase promoter activity and reduces the activation of SREBPs and their target gene expression in human hepatoma Huh-7 cells. Moreover, 4′-HF suppresses de novo fatty acid and cholesterol synthesis. This study identifies 4′-HF as an inhibitor of SREBP maturation and lipid synthesis, and provides evidence that 4′-HF may have major potential as a pharmaceutical preparation against hepatic steatosis and dyslipidemia.
- Subjects
FLAVANONES; STEROL regulatory element-binding proteins; LIPID synthesis; TRANSCRIPTION factors; GENE expression; FATTY acids; CHOLESTEROL
- Publication
FEBS Letters, 2012, Vol 586, Issue 13, p1778
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.04.060