We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bridging the gap: From protein misfolding to protein misfolding diseases
- Authors
Luheshi, Leila M.; Dobson, Christopher M.
- Abstract
Abstract: Protein misfolding and aggregation are pathognomic for a number of the most common age-related degenerative diseases. Great progress has been made in studying protein aggregation in the test tube and also in replicating protein aggregation in vertebrate animal models of these diseases. However, we argue here that the development and effective integration of emerging techniques such as the methods of nanoscience and the use of invertebrate models are now providing powerful new opportunities to advance our current understanding of the fundamental origins of these disorders.
- Subjects
PROTEIN folding; CELL aggregation; DEGENERATION (Pathology); PATHOGNOMY; AGE factors in disease; POLYACRYLAMIDE gel electrophoresis; AMYLOID beta-protein
- Publication
FEBS Letters, 2009, Vol 583, Issue 16, p2581
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2009.06.030